Knill demonstrated a fault-tolerant quantum computation scheme based on concatenated error-detecting codes and postselection with a simulated error threshold of 3% over the depolarizing channel. We show how to use Knill’s postselection scheme in a practical two-dimensional quantum architecture that we designed with the goal to optimize the error correction properties, while satisfying important architectural constraints. In our 2D architecture, one logical qubit is embedded in a tile consisting of 5×5 physical qubits. The movement of these qubits is modeled as noisy SWAP gates and the only physical operations that are allowed are local one- and two-qubit gates. We evaluate the practical properties of our design, such as its error threshold, and compare it to the concatenated Bacon-Shor code and the concatenated Steane code. Assuming that all gates have the same error rates, we obtain a threshold of 3.06 × 10−4 in a local adversarial stochastic noise model, which is the highest known error threshold for concatenated codes in 2D. We also present a Monte Carlo simulation of the 2D architecture with depolarizing noise and we calculate a pseudo-threshold of about 0.1%. With memory error rates one-tenth of the worst gate error rates, the threshold for the adversarial noise model, and the pseudo-threshold over depolarizing noise, are 4.06 × 10−4 and 0.2%, respectively. In a hypothetical technology where memory error rates are negligible, these thresholds can be further increased by shrinking the tiles into a 4 × 4 layout.