Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca

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Kumar, Rohitesh
Duffy, Sandra
Avery, Vicky M
Carroll, Anthony R
Davis, Rohan A
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2018
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Abstract

Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline–serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC50 of 7.7 μM. Microthecaline A represents the first quinoline–serrulatane alkaloid to be isolated from Nature.

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Journal of Natural Products
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APP1067728
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This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright 2018 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jnatprod.7b00992
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Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine
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