Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca
File version
Accepted Manuscript (AM)
Author(s)
Duffy, Sandra
Avery, Vicky M
Carroll, Anthony R
Davis, Rohan A
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
Size
File type(s)
Location
License
Abstract
Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline–serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC50 of 7.7 μM. Microthecaline A represents the first quinoline–serrulatane alkaloid to be isolated from Nature.
Journal Title
Journal of Natural Products
Conference Title
Book Title
Edition
Volume
81
Issue
4
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
NHMRC
Grant identifier(s)
APP1067728
Rights Statement
Rights Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright 2018 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jnatprod.7b00992
Item Access Status
Note
Access the data
Related item(s)
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine