Naseseazine C, a new anti-plasmodial dimeric diketopiperazine from a marine sediment derived Streptomyces sp.
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Buedenbender, Larissa
Grkovic, Tanja
Duffy, Sandra
Kurtboke, D Ipek
Avery, Vicky M
Carroll, Anthony R
Grkovic, Tanja
Duffy, Sandra
Kurtboke, D Ipek
Avery, Vicky M
Carroll, Anthony R
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Date
2016
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Abstract
A new dimeric diketopiperazine, naseseazine C, and the known naseseazines A and B were isolated from solid culture extracts of an Australian marine sediment derived Streptomyces species. Naseseazine C displayed a new C-6′/C-3 linkage between the two diketopiperazine subunits and showed moderate activity against the chloroquine-sensitive malaria parasite, Plasmodium falciparum (3D7 strain).
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Tetrahedron Letters
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57
Issue
52
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Medicinal and biomolecular chemistry
Medicinal and biomolecular chemistry not elsewhere classified
Organic chemistry
Biochemistry and cell biology