Androgen Signaling in Other Body Systems
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McEwan, Iain J
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Smith, Lee B
Mitchell, Rod T
McEwan, Iain J
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Abstract
The seminal vesicles (SVs) depend on androgen action for normal development and function (George and Wilson 1994; Mooradian et al. 1987; Wilson et al. 1981). Androgen action in SVs is mediated via DHT rather than T as SV stromal cells express 5α-reductase type 2, which converts T to DHT. This is supported by the observation that 5α-reductase knockout mice have smaller SVs (Mahendroo et al. 2001).
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Testosterone: From Basic Research to Clinical Applications
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1st
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Biochemistry and cell biology
Science & Technology
Life Sciences & Biomedicine
Andrology
Reproductive Biology
Endocrinology & Metabolism
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Smith, LB; McEwan, IJ, Androgen Signaling in Other Body Systems, Testosterone: From Basic Research to Clinical Applications, 2013, pp. 37-57