This paper is the second of three that collectively provides an account of the Aboriginal ethnobotany of the South East of South Australia. It concerns the use of the flora as food, medicine and narcotics. The plant uses documented include species of importance to hunter-gatherers and those that Aboriginal people utilised after European settlement. These data were drawn from a wide range of sources that includes the fragmented historical record, selected accounts from contiguous areas, and fieldwork conducted in the 1980s and 1990s.