Platinum complexes act as shielding agents against virus infection
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Author(s)
Gorle, Anil K
Dirr, Larissa
Malde, Alpeshkumar K
Farrell, Nicholas P
Berners-Price, Susan J
von Itzstein, Mark
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Abstract
We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cell-surface glycosaminoglycans. Our detailed mechanistic investigation demonstrates that TriplatinNC blocks viral entry by shielding cells from virus attack, opening new directions for metalloshielding antiviral drug development.
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Chemical Communications
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57
Issue
38
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Virology
Clinical sciences
Chemical sciences
Engineering
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
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Bailly, B; Gorle, AK; Dirr, L; Malde, AK; Farrell, NP; Berners-Price, SJ; von Itzstein, M, Platinum complexes act as shielding agents against virus infection, Chemical Communications, 2021, 57 (38), pp. 4666-4669