Generation of airborne particles toward inhalation drug delivery via electro-neutralization electrospray

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Vu, HD
Nguyen, TD
Vu, TH
Mai, LN
Van Anh Hoang, T
Tran, DDH
Nguyen, TH
Zhu, Y
Dao, DV
Thanh Dau, V
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2024
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Kyoto, Japan

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Abstract

This paper reports a one-step aerosol generation and delivery method based on electrohydrodynamic atomization (EHDA) for pulmonary drug delivery. By using inflight electro-neutralization electrospray (IFENE), the surface charge of particles was significantly reduced, allowing the generated aerosols to travel freely in open space while still having the desirable size. The IFENE method delivery ability was demonstrated by generating particles from different types of polymeric solution. The results showed that particles from IFENE method had the size distribution lying in the respirable range (lower than 5 μm) and surface charge significantly lower than normal electrospray and other inhalation devices. Along with the simple design, IFENE shows great potential to become a one-step pulmonary drug delivery device for various biomedical applications.

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2024 IEEE 19th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

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Biomedical and clinical sciences

Nanobiotechnology

Industrial biotechnology

Pharmacology and pharmaceutical sciences

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Vu, HD; Nguyen, TD; Vu, TH; Mai, LN; Van Anh Hoang, T; Tran, DDH; Nguyen, TH; Zhu, Y; Dao, DV; Thanh Dau, V, Generation of airborne particles toward inhalation drug delivery via electro-neutralization electrospray, 2024 IEEE 19th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS), 2024