Exploiting the apicoplast: apicoplast-targeting drugs and malaria vaccine development
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Stanisic, Danielle I
Good, Michael F
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Abstract
The apicoplast, a relic plastid found in most Apicomplexan parasites, is a notable drug target. Certain antibiotics elicit a delayed death phenotype by targeting this organelle. Here, we review apicoplast-targeting drugs and their targets, particularly those that cause delayed death, and highlight its potential uses in malaria vaccine development.
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Microbes and Infection
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© 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
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Subject
Microbiology
Immunology
Medical microbiology
Medical microbiology not elsewhere classified