Secoiridoids and Iridoids from Morinda asteroscepa
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Makungu, Marco
Munissi, Joan JE
Duffy, Sandra
Puttreddy, Rakesh
von der Heiden, Daniel
Rissanen, Kari
Avery, Vicky M
Nyandoro, Stephen S
Erdélyi, Máté
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Abstract
The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4-7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1-3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7).
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Journal of Natural Products
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© 2020 American Chemical Society and American Society of Pharmacognosy. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
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Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine
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Zandi, L; Makungu, M; Munissi, JJE; Duffy, S; Puttreddy, R; von der Heiden, D; Rissanen, K; Avery, VM; Nyandoro, SS; Erdélyi, M, Secoiridoids and Iridoids from Morinda asteroscepa, Journal of Natural Products, 2020