Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis
File version
Version of Record (VoR)
Author(s)
Kodagoda Gamage, SM
Gopalan, V
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
Size
File type(s)
Location
Abstract
The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress. However, its roles in preventing carcinogenesis in response to high levels of heme are not thoroughly understood. This study reviews various mechanisms associated with the paradoxical role of HMOX1, which is advantageous for tumor growth, refractoriness, and survival of cancer cells amid oxidative stress in heme-induced CRC. The alternate role of HMOX1 promotes cell proliferation and metastasis through immune modulation and angiogenesis. Inhibiting HMOX1 has been found to reverse tumor promotion. Thus, HMOX1 acts as a conditional tumor promoter in CRC pathogenesis.
Journal Title
Cancer Pathogenesis and Therapy
Conference Title
Book Title
Edition
Volume
2
Issue
2
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
© 2023 The Author(s). Published by Elsevier B.V. on behalf of Chinese Medical Association (CMA). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Item Access Status
Note
Access the data
Related item(s)
Subject
Oncology and carcinogenesis
Persistent link to this record
Citation
Singhabahu, R; Kodagoda Gamage, SM; Gopalan, V, Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis, Cancer Pathogenesis and Therapy, 2024, 2 (2), pp. 65-73