Regrowth and replacement are two basic responses of the body to any injury. While regrowth is generally attributed to stem cells, and replacement or scarring to non-stem cells, there is much more to the repair process than that. Contrary to popular belief, non-stem cells have many more roles to play in the tissue repair and regeneration than just the scar formation. Moreover, there are several other pathways to tissue regrowth and functional regeneration than with the stem cells. Several natural healing processes result in functional regrowth using non-stem cells such as olfactory ensheathing cells, Schwann cells, osteoblasts, and chondroblasts. Additionally, numerous other approaches, clinically available and under exploration, also make use of non-stem cells. This chapter explores the benefits and drawbacks of using non-stem cells, and delves into the approaches employing them.