Synthesis and antimalarial evaluation of novel benzopyrano[4,3-b]benzopyran derivatives
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Black, David StC
Andrews, Katherine T
Fisher, Gillian M
Davis, Rohan A
Kumar, Naresh
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Abstract
7-Methoxyflavenes and 5,7,8-trimethoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate the benzopyrano[4,3-b]benzopyran ring system present in the natural product, dependensin. Dependensin and its analogs were subjected to antimalarial growth inhibition assays against Plasmodium falciparum and found to have IC50 values ranging between 1.9 and 3.9 μM.
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Bioorganic & Medicinal Chemistry
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19
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17
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© 2011 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
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Subject
Medicinal and biomolecular chemistry
Organic chemistry
Infectious agents
Pharmacology and pharmaceutical sciences
Biochemistry and cell biology