Osteoporosis and bisphosphonates-related osteonecrosis of the jaw: Not just a sporadic coincidence - A multi-centre study

No Thumbnail Available
File version
Author(s)
Otto, Sven
Abu-Id, Mario Hakim
Fedele, Stefano
Warnke, Patrick H.
Becker, Stephan T.
Kolk, Andreas
Mücke, Thomas
Mast, Gerson
Köhnke, Robert
Volkmer, Elias
Haasters, Florian
Lieger, Olivier
Iizuka, Tateyuki
Porter, Stephen
Campisi, Giuseppina
Colella, Giuseppe
Ploder, Oliver
Neff, Andreas
Wiltfang, Jörg
Ehrenfeld, Michael
Kreusch, Thomas
Wolff, Klaus-Dietrich
Stürzenbaum, Stephen R.
Schieker, Matthias
Pautke, Christoph
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2011
Size
File type(s)
Location
License
Abstract

Introduction Bisphosphonates (BPs) are powerful drugs that inhibit bone metabolism. Adverse side effects are rare but potentially severe such as bisphosphonate-related osteonecrosis of the jaw (BRONJ). To date, research has primarily focused on the development and progression of BRONJ in cancer patients with bone metastasis, who have received high dosages of BPs intravenously. However, a potential dilemma may arise from a far larger cohort, namely the millions of osteoporosis patients on long-term oral BP therapy. Patients and methods This current study assessed 470 cases of BRONJ diagnosed between 2004 and 2008 at eleven different European clinical centres and has resulted in the identification of a considerable cohort of osteoporosis patients suffering from BRONJ. Each patient was clinically examined and a detailed medical history was raised. Results In total, 37/470 cases (7.8%) were associated with oral BP therapy due to osteoporosis. The majority (57%) of affected individuals did not have any risk factors for BRONJ as defined by the American Association of Oral and Maxillofacial Surgery. The average duration of BP intake of patients without risk factors was longer and the respective patients were older compared to patients with risk factors, but no statistical significant difference was found. In 78% of patients the duration of oral BP therapy exceeded 3 years prior to BRONJ diagnosis. Discussion The results from this study suggest that the relative frequency of osteoporosis patients on oral BPs suffering from BRONJ is higher than previously reported. There is an urgent need to substantiate epidemiological characteristics of BRONJ in large cohorts of individuals.

Journal Title

Journal of Cranio-Maxillofacial Surgery

Conference Title
Book Title
Edition
Volume

39

Issue

4

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject

Dentistry not elsewhere classified

Clinical Sciences

Dentistry

Persistent link to this record
Citation
Collections