This paper presents the development of a cutting force model for the micro-end-milling processes under various cutting conditions using a hybrid approach. Firstly, a finite element (FE) model of orthogonal micro-cutting with a round cutting edge is developed for medium-carbon steel. A number of finite element analyses (FEA) are performed at different uncut chip thicknesses and velocities. Based on the FEA results, the cutting force coefficients are extracted through a nonlinear algorithm to establish a relationship with the uncut chip thickness and cutting speed. Then, the cutting force coefficients are integrated into a mechanistic cutting force model, which can predict cutting forces under different cutting conditions. In order to account for the cutting edge effect, an effective rake angle is employed for the determination of the cutting force. A comparison of the prediction and experimental measured cutting forces has shown that the developed method provides accurate results.