Synthesis of Cholesterol Glycoconjugates for Targeted Liposomal Drug Delivery
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Pan, Yuchen
Al Nahain, Abdullah
Clarke, Daniel
McMillan, Nigel A
Ferro, Vito
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Abstract
Herein we describe the synthesis of cholesterol glycoconjugates containing D-glucosyl or D-galactosyl moieties for potential use in targeted liposomal drug delivery to the brain and liver, respectively. The glycoconjugates were synthesized via a modular strategy utilizing the Cu(I)-catalysed Huisgen azide-alkyne cycloaddition reaction, building on previous studies with D-mannose.The conjugates comprised a single monosaccharide unit joined to cholesterol via an optimized, bifunctional PEG -based linker 4
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Trends in Carbohydrate Research
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12
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3
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Clinical sciences
Science & Technology
Physical Sciences
Chemistry, Organic
glycoconjugate synthesis
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Nguyen, H; Pan, Y; Al Nahain, A; Clarke, D; McMillan, NA; Ferro, V, Synthesis of Cholesterol Glycoconjugates for Targeted Liposomal Drug Delivery, Trends in Carbohydrate Research, 2020, 12 (3), pp. 1-9