The resources and energy sectors make a significant contribution to economic performance in the economies of West Asia. In this study we explore the effect ambitious policies for resource efficiency and greenhouse gas abatement would have on West Asian economies and what their contribution to environmental sustainability could look like. We employ the Global Trade and Environmental Resource Model (GTEM-Resource) to empirically assess the economic and environmental implications of global policy initiatives in the region. Results show that resource efficiency and greenhouse gas (GHG) abatement policies are complementary in their effects. Resource efficiency policies boost resource use productivity in the region, reduce all categories of material extraction based on sustainable consumption and production behaviour and also caused by trade, and foster economic performance. By contrast, GHG emission abatement policies have a small effect on resource productivity but drive significant GHG reductions that are accompanied by reduced economic performance. When these two policies are combined, real GDP in West Asia is projected to increase by 8% relative to business-as-usual by 2060, while resource extraction and GHG emissions levels in the region would decline dramatically by 40% and 50%, respectively. Saudi Arabia and the United Arab Emirates would be much better off, compared to other countries in the region, with large increases in real GDP and major reductions in GHG emissions and resource extraction levels. Findings suggest that technology development and climate mitigation policies would result in a win-win solution for all countries in West Asia, contributing to maintaining well-being and protecting the environment on regional and global scales. This shows that there is a pathway to economic prosperity for resource-rich countries and regions.