Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation
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Lambie, Duncan
Wilmott, James S
Pinder, Alex
Pavey, Sandra
Kim-Anh, Le Cao
Akalin, Taner
Karaarslan, Isil Kilinc
Ozdemir, Fezal
Scolyer, Richard A
Yamada, Miko
Soyer, H Peter
Schaider, Helmut
Gabrielli, Brian
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Abstract
Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple markers associated with melanoma, suggesting that these represent naevi with an increased potential for transformation to melanoma.
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Pigment Cell & Melanoma Research
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29
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4
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© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Fox, C; Lambie, D; Wilmott, JS; Pinder, A; Pavey, S; Kim-Anh, LC; Akalin, T; Karaarslan, IK; Ozdemir, F; Scolyer, RA; Yamada, M; Soyer, HP; Schaider, H; Gabrielli, B, Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation, Pigment Cell & Melanoma Research, 2016, 29 (4), pp. 444-452, which has been published in final form at https://doi.org/10.1111/pcmr.12489. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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Biological sciences
Biomedical and clinical sciences
Science & Technology
Life Sciences & Biomedicine
Oncology
Cell Biology
Dermatology
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Fox, C; Lambie, D; Wilmott, JS; Pinder, A; Pavey, S; Kim-Anh, LC; Akalin, T; Karaarslan, IK; Ozdemir, F; Scolyer, RA; Yamada, M; Soyer, HP; Schaider, H; Gabrielli, B, Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation, Pigment Cell & Melanoma Research, 2016, 29 (4), pp. 444-452