Early stage glottic cancers present with a combination of symptoms such as altered voice resonance, pain, dyspepsia, heartburn, cough etc., that often overlap with other common diseases affecting the human body. The analogous symptoms and lack of functional impairment can delay early diagnosis, which in turn can influence loco-regional control of glottic cancers. The heterogeneous nature of head and neck cancers, as well as the diversity of patient characteristics, has precluded the clinicians from using simple algorithms in the early stage glottic cancers. This, in turn, has generated an ongoing debate, as to whether upfront surgery or chemoradiation should be used as the primary modality of treatment.