Endiandrin A, a Potent Glucocorticoid Receptor Binder Isolated from the Australian Plant Endiandra anthropophagorum
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Carroll, Anthony R
Duffy, Sandra
Avery, Vicky M
Guymer, Gordon P
Forster, Paul I
Quinn, Ronald J
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Abstract
Bioassay-guided fractionation of the DCM extract from the roots of Endiandra anthropophagorum resulted in the isolation of a new cyclobutane lignan, endiandrin A (1), together with the known natural products nectandrin B (2) and (-)-dihydroguaiaretic acid (3). The structure of 1 was determined by extensive 1D and 2D NMR and MS data analyses. Acetylation and methylation of 1 yielded di-O-acetylendiandrin A (4) and di-O-methylendiandrin A (5), respectively. All compounds were tested in a glucocorticoid receptor binding assay and displayed IC50 values ranging from 0.9 to 35 卮
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Journal of Natural Products
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70
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This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright 2007 American Chemical Society and the American Society of Pharmacognosy after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np070073x
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Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine