Too much of a good thing: two cases of disseminated intravascular coagulation-like coagulopathy in patients with decompensated cirrhosis after administration of Prothrombinex-VF (Letter)
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Robinson, Claire
Wood, Peter
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A 50-year-old man with decompensated Child Pugh C cirrhosis (CP-C) (MELD-Na 25) presented with fevers. He was treated empirically for spontaneous bacterial peritonitis, with i.v. Ceftriaxone 2 g, diuretics and Pabrinex. At presentation, he had a deranged coagulation profile with an international normalised ratio (INR) of 2.2, prothrombin time (PT) of 26 s, activated partial thromboplastin time (APTT) 49 s and fibrinogen (clottable) 1.0 g/L. In preparation for a diagnostic paracentesis, 4000 units (25 IU/kg) of Prothrombinex-VF (a prothrombin complex concentrate (PCC)) and 10 mg i.v. vitamin K was administered.
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Internal Medicine Journal
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49
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5
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Clinical sciences
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Medicine, General & Internal
General & Internal Medicine
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Harwood, M; Robinson, C; Wood, P, Too much of a good thing: two cases of disseminated intravascular coagulation-like coagulopathy in patients with decompensated cirrhosis after administration of Prothrombinex-VF (Letter), Internal Medicine Journal, 2019, 49 (5), pp. 679-680