To understand the complex dynamics which impact on Australia’s university students’ mental health (MH), this paper presents qualitative data that demonstrates the relationships which exists between four domains (personal, university, home, and community) and their impact on students’ MH. Bronfenbrenner’s socio-ecological model was used, as an interpretive lens, to give descriptive insights concerned with the MH crisis occurring across higher educational settings. Positioned within an interpretivist paradigm, this research collected data from participants (n = 934), requesting for either their lived or witnessed experiences concerning MH issues. Qualitative data were sorted and analysed using Creswell’s thematic coding techniques as well as Leximancer software for concept development. Bronfenbrenner’s socio-ecological model was employed to develop a conceptual framework to explain the multidimensional relationships associated with MH and their interconnections across the four domains. The paper concludes by providing insight into the interrelated nature of MH and Australia’s university students.