Letter to the editor: is HIF-1 alpha a viable prognostic indicator in OSCC? A critical review of a meta-analysis study
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Kumarasamy, Chellan
Royam, Madhav Madurantakam
Devi, Arikketh
Baxi, Siddharta
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Abstract
The study performed by Zhou et al. (World J Surg Oncol 15:104, 2017) titled "Clinical and prognostic significance of HIF-1α overexpression in oral squamous cell carcinoma: a meta-analysis" attempts to highlight hypoxia-inducible factor-1 alpha as a possible prognostic marker in oral squamous cell carcinoma (OSCC). We would like to underline a few points which may affect such a conclusion. The correlations between HIF-1α expression and tumour size as well as tumour stage are debatable. Further, the subgroup analysis incorporating Australia and Europe into a single subgroup limits the viability of the prognostic analysis of HIF-1α. We also suggest future studies in the same research area to analyse head and neck squamous cell carcinoma instead of OSCC, to ameliorate the limitations encountered by Zhou et al., due to the scarcity of relevant clinical data and a low number of studies about OSCC.
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World Journal of Surgical Oncology
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16
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1
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© The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Clinical sciences
Oncology and carcinogenesis
Ophthalmology
Science & Technology
Life Sciences & Biomedicine
Surgery
Letter to the editor
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Jayaraj, R; Kumarasamy, C; Royam, MM; Devi, A; Baxi, S, Letter to the editor: is HIF-1 alpha a viable prognostic indicator in OSCC? A critical review of a meta-analysis study, World Journal of Surgical Oncology, 2018, 16 (1), pp. 111:1-111:2