Bio-sensing with butterfly wings: naturally occurring nano-structures for SERS-based malaria parasite detection
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Sekine, Ryo
Dixon, Matthew WA
Tilley, Leann
Bambery, Keith R
Wood, Bayden R
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Abstract
Surface enhanced Raman scattering (SERS) is a powerful tool with great potential to provide improved bio-sensing capabilities. The current ‘gold-standard’ method for diagnosis of malaria involves visual inspection of blood smears using light microscopy, which is time consuming and can prevent early diagnosis of the disease. We present a novel surface-enhanced Raman spectroscopy substrate based on gold-coated butterfly wings, which enabled detection of malarial hemozoin pigment within lysed blood samples containing 0.005% and 0.0005% infected red blood cells.
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Physical Chemistry Chemical Physics
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17
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© 2015 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
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Subject
Physical sciences
Other physical sciences not elsewhere classified
Chemical sciences
Engineering
Bio-sensing
Nano-structures
Malaria parasite detection
Raman scattering (SERS)