A PRISMA-compliant meta-analysis on association between X-ray repair cross complementing (XRCC1, XRCC2, and XRCC3) polymorphisms and oral cancer susceptibility
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Rostamnia, Maryam
Sharifi, Roohollah
Safaei, Mohsen
Zavattaro, Elisa
Tadakamadla, Santosh Kumar
Imani, Mohammad Moslem
Sadeghi, Masoud
Golshah, Amin
Moradpoor, Hedaiat
Rezaei, Farzad
Omidpanah, Neda
Hatami, Masoud
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Abstract
Background: Oral Cancer (OC) is one of the leading causes of death and the disease mainly occurs over 50 years of age. Herein, a meta-analysis aimed to assess the association between X-ray repair cross complementing (XRCC) polymorphisms and OC risk. Methods: Four databases were searched extensively until June 5, 2020. Subgroup analysis, meta-regression, and funnel plots, as well as the quality assessment were estimated. Results: Fifteen studies were entered to the analysis. With regards to allele, homozygote, heterozygote, recessive, and dominant models, the pooled ORs for XRCC1 rs1799782 polymorphism were 1.51 (P = 0.01), 1.45 (P = 0.11), 1.45 (P = 0.0003), 1.44 (P = 0.0002), and 1.29 (P = 0.26); for XRCC1 rs1799782 polymorphism were 1.65 (P = 0.11), 1.50 (P = 0.33), 1.06 (P = 0.83), 1.57 (P = 0.12), and 1.32 (P = 0.45); for XRCC1 rs25489 polymorphism were 0.01 (P = 0.19), 1.44 (P = 0.48), 1.21 (P = 0.72), 1.17 (P = 0.19), and 1.38 (P = 0.54); for XRCC2 rs2040639 polymorphism were 0.68 (P = 0.0002), 0.63 (P = 0.02), 0.95 (P = 0.92), 0.79 (P = 0.49), and 0.61 (P = 0.005); and for XRCC3 rs861539 polymorphism were 1.24 (P = 0.20), 1.28 (P = 0.48), 0.99 (P = 0.95), 1.15 (P = 0.46), and 1.52 (P = 0.15), respectively. Conclusions: The T allele and CT genotype of XRCC1 rs1799782 polymorphism had an elevated risk, whereas the G allele and GG genotype of XRCC2 rs2040639 polymorphism had a protective role in OC.
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Gene
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781
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Genetics
Zoology
Medical microbiology
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
Oral carcinoma
Oral squamous cell carcinoma
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Mozaffari, HR; Rostamnia, M; Sharifi, R; Safaei, M; Zavattaro, E; Tadakamadla, SK; Imani, MM; Sadeghi, M; Golshah, A; Moradpoor, H; Rezaei, F; Omidpanah, N; Hatami, M, A PRISMA-compliant meta-analysis on association between X-ray repair cross complementing (XRCC1, XRCC2, and XRCC3) polymorphisms and oral cancer susceptibility, Gene, 2021, 781, pp. 145524