A PRISMA-compliant meta-analysis on association between X-ray repair cross complementing (XRCC1, XRCC2, and XRCC3) polymorphisms and oral cancer susceptibility

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Mozaffari, Hamid Reza
Rostamnia, Maryam
Sharifi, Roohollah
Safaei, Mohsen
Zavattaro, Elisa
Tadakamadla, Santosh Kumar
Imani, Mohammad Moslem
Sadeghi, Masoud
Golshah, Amin
Moradpoor, Hedaiat
Rezaei, Farzad
Omidpanah, Neda
Hatami, Masoud
Griffith University Author(s)
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2021
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Abstract

Background: Oral Cancer (OC) is one of the leading causes of death and the disease mainly occurs over 50 years of age. Herein, a meta-analysis aimed to assess the association between X-ray repair cross complementing (XRCC) polymorphisms and OC risk. Methods: Four databases were searched extensively until June 5, 2020. Subgroup analysis, meta-regression, and funnel plots, as well as the quality assessment were estimated. Results: Fifteen studies were entered to the analysis. With regards to allele, homozygote, heterozygote, recessive, and dominant models, the pooled ORs for XRCC1 rs1799782 polymorphism were 1.51 (P = 0.01), 1.45 (P = 0.11), 1.45 (P = 0.0003), 1.44 (P = 0.0002), and 1.29 (P = 0.26); for XRCC1 rs1799782 polymorphism were 1.65 (P = 0.11), 1.50 (P = 0.33), 1.06 (P = 0.83), 1.57 (P = 0.12), and 1.32 (P = 0.45); for XRCC1 rs25489 polymorphism were 0.01 (P = 0.19), 1.44 (P = 0.48), 1.21 (P = 0.72), 1.17 (P = 0.19), and 1.38 (P = 0.54); for XRCC2 rs2040639 polymorphism were 0.68 (P = 0.0002), 0.63 (P = 0.02), 0.95 (P = 0.92), 0.79 (P = 0.49), and 0.61 (P = 0.005); and for XRCC3 rs861539 polymorphism were 1.24 (P = 0.20), 1.28 (P = 0.48), 0.99 (P = 0.95), 1.15 (P = 0.46), and 1.52 (P = 0.15), respectively. Conclusions: The T allele and CT genotype of XRCC1 rs1799782 polymorphism had an elevated risk, whereas the G allele and GG genotype of XRCC2 rs2040639 polymorphism had a protective role in OC.

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Gene

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781

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Genetics

Zoology

Medical microbiology

Science & Technology

Life Sciences & Biomedicine

Genetics & Heredity

Oral carcinoma

Oral squamous cell carcinoma

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Mozaffari, HR; Rostamnia, M; Sharifi, R; Safaei, M; Zavattaro, E; Tadakamadla, SK; Imani, MM; Sadeghi, M; Golshah, A; Moradpoor, H; Rezaei, F; Omidpanah, N; Hatami, M, A PRISMA-compliant meta-analysis on association between X-ray repair cross complementing (XRCC1, XRCC2, and XRCC3) polymorphisms and oral cancer susceptibility, Gene, 2021, 781, pp. 145524

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