The present work provides an empirical investigation on the thermal characteristics of Ag/oil nanofluids flow inside a sinusoidal tube under a constant heat flux boundary condition. Ag/oil nanofluids have been prepared in low-volume concentrations of 0.011%, 0.044%, and 0.171%. The average size of the nanoparticles was 20 nm. A heated coil was attached to the upper and lower surface of the tube that satisfied the constant thermal boundary condition of 204 W. The experiment has been pursued at low Reynolds numbers less than 160. A loop was designed to keep the flow hydrodynamically fully developed during the experiment. The test case was a sinusoidal tube. Upper and lower surfaces of the tube have been designed sinusoidally. Moreover, the width of the plates was long enough, so the problem was not considerably affected by the three-dimensional releasing effect. Convective heat transfer coefficient and Nusselt number were calculated. It has been observed that based on the acquired data of the present work, convective heat transfer coefficient increased up to 23% for the best case (nanofluid with a volume concentration of 0.171%) compared to the base fluid. This happened while the rise of the friction factor was very low. In addition, a comparison between the new results and the previous work by authors showed the positive performance of sinusoidal tubes in increasing the convective heat transfer coefficient (the average increase was calculated to be about 82%) compared to the annular tube.