Dengue is the most common arboviral infection globally, and causes significant morbidity, mortality and economic burden. There is currently no vaccine or chemotherapeutic treatment available, and a greater understanding of viral pathogenesis is required so that effective treatments can be developed. The research in this PhD thesis is focused on using carbohydrate-based probes to explore two essential aspects of the dengue virus (DENV) lifecycle; the virus-host cell interaction involved in the viral cell entry process, and the replication of viral RNA. [...]