The Invitro Cytotoxicity and DNA Alkylating Ability of the Simplest Functional Analogues of the Seco CC-1065 Alkylating Subunit
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White, Rodney
Parsons, Peter G.
Prakash, Arungundrum S.
Young, David
Parsons, Peter G.
Prakash, Arungundrum S.
Young, David
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1995
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Abstract
The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.
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Bioorganic & Medicinal Chemistry Letters
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5
Issue
16
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Chemical sciences
Medicinal and biomolecular chemistry
Organic chemistry
Pharmacology and pharmaceutical sciences