Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane

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Battle, Andrew R
Valenzuela, Stella M
Mechler, Adam
Nichols, Ryan J
Praporski, Slavica
di Maio, Isabelle L
Islam, Hedoyetul
Cirard-Egrot, Agnes P
Cornell, Bruce A
Prashar, Jog
Caruso, Frank
Martin, Lisandra L
Martin, Donald K
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2009
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Abstract

The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of "smart" biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.

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Advanced Functional Materials

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19

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2

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Physical sciences

Chemical sciences

Engineering

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