Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties
No Thumbnail Available
File version
Author(s)
Fagan, Vincent
Hussein, Waleed M
Su, Mei
Giddam, Ashwini K
Batzloff, Michael R
Good, Michael F
Toth, Istvan
Simerska, Pavla
Hussein, Waleed M
Su, Mei
Giddam, Ashwini K
Batzloff, Michael R
Good, Michael F
Toth, Istvan
Simerska, Pavla
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2017
Size
File type(s)
Location
License
Abstract
Four group A streptococcal glycolipopeptide vaccine candidates with different lipidic adjuvanting moieties were prepared and characterized. The immunogenicity of the compounds was evaluated by macrophage and dendritic cell uptake studies and by in vivo quantification of systemic IgG antibody by ELISA. Three of the candidates showed significant induction of the IgG response.
Journal Title
ChemBioChem
Conference Title
Book Title
Edition
Volume
18
Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject
Inorganic chemistry not elsewhere classified
Medicinal and biomolecular chemistry
Biochemistry and cell biology