Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection
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Bloxham, CJ
Chiu, H
Chew, KY
Russell, J
Yoshikawa, Y
Bielefeldt-Ohmann, H
Steele, LE
Hulme, KD
Verzele, NAJ
Noye, EC
Wu, M
Reichelt, ME
Thomas, WG
et al.
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Abstract
People with diabetes mellitus are susceptible to both cardiovascular disease and severe influenza A virus infection. We hypothesized that diabetes also increases risks of influenza-associated cardiac complications. A murine type 1 (streptozotocin-induced) diabetes model was employed to investigate influenza-induced cardiac distress. Lung histopathology and viral titres revealed no difference in respiratory severity between infected control and diabetic mice. However, compared with infected control mice, infected diabetic mice had increased serum cardiac troponin I and creatine-kinase MB, left ventricular structural changes and right ventricular functional alterations, providing the first experimental evidence of type I diabetes increasing risks of influenza-induced cardiovascular complications.
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Frontiers in Cellular and Infection Microbiology
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11
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© 2021 Sinclair, Bloxham, Chiu, Chew, Russell, Yoshikawa, Bielefeldt-Ohmann, Steele, Hulme, Verzele, Noye, Wu, Reichelt, Thomas, Gallo, Redd and Short. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Medical microbiology
Endocrinology
Virology
Cardiology (incl. cardiovascular diseases)
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Sinclair, JE; Bloxham, CJ; Chiu, H; Chew, KY; Russell, J; Yoshikawa, Y; Bielefeldt-Ohmann, H; Steele, LE; Hulme, KD; Verzele, NAJ; Noye, EC; Wu, M; Reichelt, ME; Thomas, WG; et al., Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection, Frontiers in Cellular and Infection Microbiology, 2021, 11, pp. 714440