A Meta-learning based Graph-Hierarchical Clustering Method for Single Cell RNA-Seq Data

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Pan, Z
Zeng, Y
Lin, Y
Yu, W
Zhang, H
Yang, Y
Griffith University Author(s)
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2022
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Las Vegas, USA

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Single cell sequencing techniques enable researchers view complex bio-tissues from a more precise perspective to identify cell types. However, more and more recent works have been done to find more detailed subtypes within already known cell types. Here, we present MeHi-SCC, a method which utilized meta-learning protocol and brought in multi scRNA-seq datasets' information in order to assist graph-based hierarchical sub-clustering process. In result, MeHi-SCC outperformed current-prevailing scRNA clustering methods and successfully identified cell subtypes in two large scale cell atlas. Our codes and datasets are available online at https://github.com/biomed-AI/MeHi-SCC

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2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

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Sequence analysis

Biomedical instrumentation

Biochemistry and cell biology not elsewhere classified

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Pan, Z; Zeng, Y; Lin, Y; Yu, W; Zhang, H; Yang, Y, A Meta-learning based Graph-Hierarchical Clustering Method for Single Cell RNA-Seq Data, 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2022, pp. 226-232