Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy

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Yang, Ying
Gao, Peng
Wang, Juan
Tu, Qiufen
Bai, Long
Xiong, Kaiqin
Qiu, Hua
Zhao, Xin
Maitz, Manfred F
Wang, Huaiyu
Li, Xiangyang
Zhao, Qiang
Xiao, Yin
Huang, Nan
Yang, Zhilu
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2020
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http://creativecommons.org/licenses/by/4.0/
Abstract

Stenting is currently the major therapeutic treatment for cardiovascular diseases. However, the nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response, thrombogenic reactions, smooth muscle cell hyperproliferation accompanied by the delayed arterial healing, and poor reendothelialization, thus leading to restenosis along with late stent thrombosis. To address prevalence critical problems, we present an endothelium-mimicking coating capable of rapid regeneration of a competently functioning new endothelial layer on stents through a stepwise metal (copper)-catechol-(amine) (MCA) surface chemistry strategy, leading to combinatorial endothelium-like functions with glutathione peroxidase-like catalytic activity and surface heparinization. Apart from the stable nitric oxide (NO) generating rate at the physiological level (2:2 × 10a'10 mol/cm2/min lasting for 60 days), this proposed strategy could also generate abundant amine groups for allowing a high heparin conjugation efficacy up to ∼1 μg/cm2, which is considerably higher than most of the conventional heparinized surfaces. The resultant coating could create an ideal microenvironment for bringing in enhanced antithrombogenicity, anti-inflammation, anti-proliferation of smooth muscle cells, re-endothelialization by regulating relevant gene expressions, hence preventing restenosis in vivo. We envision that the stepwise MCA coating strategy would facilitate the surface endothelium-mimicking engineering of vascular stents and be therefore helpful in the clinic to reduce complications associated with stenosis.

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© 2020 Ying Yang et al. Exclusive Licensee Science and Technology Review Publishing House. Distributed under a Creative Commons Attribution License (CC BY 4.0).
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Cardiovascular medicine and haematology
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
NITRIC-OXIDE RELEASE
DRUG-ELUTING STENTS
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Yang, Y; Gao, P; Wang, J; Tu, Q; Bai, L; Xiong, K; Qiu, H; Zhao, X; Maitz, MF; Wang, H; Li, X; Zhao, Q; Xiao, Y; Huang, N; Yang, Z, Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy, Research, 2020, 2020, pp.9203906
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