Coronavirus pandemic has caused severe impact on low-income to lower-middle economies, compared to the high-income economies. Small and impoverished states of South Asia have been hit hard by the pandemic. They have had to bear the harsher impact as these countries have a high-density population, poor health infrastructure, poor access to basic health services, and wide economic and social disparities. In addition, the poor economies of these countries have been weakened further, mainly by extended lock downs. Such impacts have made South Asian nations more vulnerable to big power influences like India, China, and the United States. This chapter, in this context, examines how these big powers are competing in the region and how it could be an opportunity for South Asian nations to benefit from strategic engagements in the region. This chapter concludes that despite the pandemic diplomacy of great powers for geopolitical competition in the region, the smaller South Asian nations need to deal with big powers proactively to benefit from their support packages, including their vaccine aid. It will also be vital for small powers to strengthen the regional platforms like SAARC and push the Coronavirus-related problems.