Aberrant trafficking of transmembrane proteins in human disease

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Cobbold, C
Monaco, AP
Sivaprasadarao, A
Ponnambalam, S
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2003
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Abstract

Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.

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Trends in Cell Biology

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13

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12

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Biological sciences

Biomedical and clinical sciences

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