Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia
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Heffernan, Aaron J
Naicker, Saiyuri
Henderson, Andrew
Hassen Chowdhury, Mohammed Abdul
Roberts, Jason A
Sime, Fekade B
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Abstract
Aim: To determine the prevalence of extended-spectrum β-lactamase (ESBL) and metallo-β-lactamase (MBL)-producing Escherichia coli in South Asia. Methodology: A systematic review and meta-analysis of data published in PubMed, EMBASE, Web of Science and Scopus. Results: The pooled prevalence of ESBL and MBL-producing E. coli in South Asia were 33% (95% CI: 27-40%) and 17% (95% CI: 12-24%), respectively. The prevalence of bla CTX-M type was 58% (95% CI: 49-66%) with blaCTX-M-15 being the most prevalent (51%, 95% CI: 40-62%) variant. The most prevalent MBL variant was blaNDM-1 (33%, 95% CI: 20-50%). Conclusion: This study suggests a high prevalence of ESBLs and MBLs among E. coli clinical isolates. Comprehensive resistance surveillance is required to guide clinicians prescribing antibiotics in South Asia.
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Future Microbiology
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16
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7
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Microbiology
Medical microbiology
Science & Technology
Life Sciences & Biomedicine
Escherichia coli
extended-spectrum β
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Islam, K; Heffernan, AJ; Naicker, S; Henderson, A; Hassen Chowdhury, MA; Roberts, JA; Sime, FB, Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia, Future Microbiology, 2021, 16 (7), pp. 521-535