The aim of this study was to investigate whether depressed adolescents differed from non-depressed adolescents in terms of constructs consistent with those that are proposed to underpin interpersonal psychotherapy. In particular, it was hypothesized that compared with non-depressed adolescents, depressed adolescents would demonstrate a greater number of negative life events associated with interpersonal loss and major life transitions, a more insecure attachment style and poorer communication skills, interpersonal relationships and social support. Thirty-one clinically diagnosed depressed adolescents were matched with 31 non-depressed adolescents on age, gender and socio-economic status. The 62 participants were aged between 12 and 19?years and comprised 18 male and 44 female adolescents. On a self-report questionnaire, depressed adolescents reported a greater number of negative interpersonal life events, a less secure attachment style and scored higher on all insecure attachment styles compared with the non-depressed adolescents. In addition, depressed adolescents demonstrated lower levels of social skill (on both adolescent and parent report), a poorer quality of relationship with parents (on both adolescent and parent report) and lower social competence (adolescent report only). Parents of depressed adolescents also reported more negative parental attitudes and behaviours towards their adolescent compared with parents of non-depressed adolescents. Thus, the results of this study are consistent with the constructs underlying interpersonal psychotherapy and suggest their usefulness in the assessment, conceptualization and treatment of adolescent depression. Clinical implications are discussed. Copyright 頲013 John Wiley & Sons, Ltd. Key Practitioner Message 剉ssues relating to interpersonal stress and loss, poor interpersonal relationships, insecure attachment style, and poor social skills are evident among depressed adolescents in comparison with their non-depressed peers. 剁lthough it is not clear whether these factors are causal in the development of depression or if they reflect a consequence or concomitant of the disorder, it is important that clinicians consider these variables in the case formulation. 剉nterpersonal psychotherapy addresses these variables through a focus on handling interpersonal conflicts, role transitions and interpersonal losses, and building social support and social skills.