Disposable flow cytometer with high efficiency in particle counting and sizing using an optofluidic lens

Loading...
Thumbnail Image
File version
Author(s)
Song, Chaolong
Luong, Trung-Dung
Kong, Tian Fook
Nguyen, Nam-Trung
Asundi, Anand Krishna
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2011
Size

269136 bytes

File type(s)

application/pdf

Location
License
Abstract

Flow cytometers are widely applied to environmental monitoring, industrial testing, and biochemical studies. Integrating a flow cytometer into microfluidic networks helps to miniaturize the system and make it portable for field use. The integration of optical components, such as lenses, further improves the compactness and thus has been intensively studied recently. However, the current designs suffer from severe light scattering due to the roughness of the solid-based lens interface. In this Letter, we propose a flow cytometer using an optofluidic lens to focus the light beam. Benefiting from the smooth liquid-liquid lens interface and the refractive-index matching liquid as cladding streams, a light beam can be well focused without scattering. The variations of the signal peak values are reduced, owing to the small beam width at the beam waist. The device presents an efficient and accurate performance on both the counting and sizing of particles.

Journal Title

Optics Letters

Conference Title
Book Title
Edition
Volume

36

Issue

5

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2011 OSA. This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OL.36.000657. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.

Item Access Status
Note
Access the data
Related item(s)
Subject

Atomic, molecular and optical physics

Quantum physics

Quantum physics not elsewhere classified

Persistent link to this record
Citation
Collections