Antimalarial Activity of Azafluorenone Alkaloids from the Australian Tree Mitrephora diversifolia
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Davis, Rohan A
Duffy, Sandra
Avery, Vicky M
Camp, David
Quinn, Ronald J
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Abstract
Mass-directed isolation of the CH2Cl2/MeOH extract from the roots of the Australian tree Mitrephora diversifolia resulted in the purification of the new azafluorenone alkaloid 5,8-dihydroxy-6-methoxyonychine (1) together with the known natural product 5-hydroxy-6-methoxyonychine (2). The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. Both compounds were isolated during a drug discovery program aimed at the identification of new antimalarial leads from a prefractionated natural product library. When tested against two different strains of the parasite Plasmodium falciparum (3D7 and Dd2), 2 displayed IC50 values of 9.9 and 11.4 μM, respectively, while 1 showed minimal activity.
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Journal of Natural Products
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72
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8
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This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright 2009 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/np900247f
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Subject
Chemical sciences
Biologically active molecules
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine