Enhanced Tissue Damage Following H1N1 Infection in Human Precision-Cut Lung Slices (PCLS)

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Danov, O
Martin, G
Greif, A
Bailly, B
Braubach, P
Jonigk, DD
Warnecke, G
von Itzstein, M
Sewald, K
Wronski, S
Braun, A
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2019
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Dallas, TX

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Abstract

Annual seasonal epidemics with Influenza A virus (IAV) strains result in 3-5 million severe cases in children and elderly individuals. Therefore, in this study the immune response of lower respiratory tract tissue to H1N1 (California/04/2009) pandemic strain was compared to seasonal H3N2 (Perth/16/2009) in viable human precision-cut lung slices (PCLS) ex vivo. PCLS were inoculated with 104-106 ffu/mL for 1 h and incubated 48 h post infection. Local immune response was measured with MSD, tissue damage observed by LDH release and

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

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199

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Subject

Biomedical and clinical sciences

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Life Sciences & Biomedicine

Critical Care Medicine

Respiratory System

General & Internal Medicine

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Danov, O; Martin, G; Greif, A; Bailly, B; Braubach, P; Jonigk, DD; Warnecke, G; von Itzstein, M; Sewald, K; Wronski, S; Braun, A, Enhanced Tissue Damage Following H1N1 Infection in Human Precision-Cut Lung Slices (PCLS), American Journal of Respiratory and Critical Care Medicine, 2019, 199