Over-diagnosis of rotavirus infection in infants due to detection of vaccine virus
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Ye, Suifang
Tozer, Sarah
Clark, Julia E
Bletchly, Cheryl
Lambert, Stephen B
Grimwood, Keith
Nimmo, Graeme R
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Abstract
Accurate rotavirus diagnosis is important for clinical management and monitoring active disease and vaccine effectiveness. Between 2016-2018, rotavirus-positive results in our laboratory were from vaccine virus shedding in 71/152 (46.7%) infants with a request for rotavirus testing. Routine diagnostic testing of infants should ideally distinguish vaccine from wild-type virus.
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Clinical Infectious Diseases
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© 2019 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Clinical Infectious Diseases following peer review. The definitive publisher-authenticated version Over-diagnosis of rotavirus infection in infants due to detection of vaccine virus, Clinical Infectious Diseases, 2019 is available online at: https://doi.org/10.1093/cid/ciz1196
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Subject
Biological sciences
Biomedical and clinical sciences
Clinical sciences
rotavirus
shedding
vaccine
diagnosis
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Whiley, DM; Ye, S; Tozer, S; Clark, JE; Bletchly, C; Lambert, SB; Grimwood, K; Nimmo, GR, Over-diagnosis of rotavirus infection in infants due to detection of vaccine virus, Clinical Infectious Diseases, 2019