Isolation of Antimalarial Agents From Indonesian Medicinal Plants: Swietenia mahagoni and Pluchea indica

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Nugraha, Ari S
Purnomo, Yoshinta D
Pratama, Antonius N Widhi
Triatmoko, Bawon
Hendra, Rudi
Wongso, Hendris
Avery, Vicky M
Keller, Paul A
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2022
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Abstract

Malaria is a neglected tropical disease that still demands serious efforts to tackle successfully, including the need for new antimalarial lead compounds to combat drug-resistant Plasmodium. Intensive phytochemical and pharmacological investigation into the Indonesian medicinal plants Swietenia mahagoni and Pluchea indica successfully revealed 5 constituents. Antimalarial bioassays indicated 34,5-tri-O-caffeoylquinic acid (4) to be the most active against Plasmodium falciparum 3D7 and Dd2 strains with IC50 values of 8.2 and 8.8 µM, respectively. No cytotoxicity was observed against Human Embryonic Kidney cells at a concentration of 40 µM.

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Natural Product Communications

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17

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1

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© The Author(s) 2022. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Ecology

Plant biology

Organic chemistry

Science & Technology

Life Sciences & Biomedicine

Chemistry, Medicinal

Food Science & Technology

Pharmacology & Pharmacy

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Nugraha, AS; Purnomo, YD; Pratama, ANW; Triatmoko, B; Hendra, R; Wongso, H; Avery, VM; Keller, PA, Isolation of Antimalarial Agents From Indonesian Medicinal Plants: Swietenia mahagoni and Pluchea indica, Natural Product Communications, 2022, 17 (1), pp. 1-5

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