Pharmacotherapy of Persons with Dementia in Long-term Care in Australia: A Descriptive Audit of Central Nervous System Medications

Loading...
Thumbnail Image
File version

Version of Record (VoR)

Author(s)
Moyle, Wendy
El Saifi, Najwan
Draper, Brian
Jones, Cindy
Beattie, Elizabeth
Shum, David
Thalib, Lukman
Mervin, Cindy
O'Dwyer, Siobhan
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2017
Size
File type(s)
Location
License
Abstract

Background: Neuropsychiatric symptoms of dementia are often treated through the prescription of one or more psychotropic medications. However, limited efficacy and potential harmful side-effects has resulted in efforts to reduce the use of psychotropic medication in this population, particularly for those living in long-term care.

Objectives: This study sought to describe the pattern of central nervous system medication usage in older adults with dementia living in long-term care; assess the appropriateness of prescribing against Beers criteria; and detect potential drug interactions from co-administered medications. Methods: A retrospective descriptive audit of the medical records of n=415 residents, aged >60 years with a diagnosis of dementia, from 28 long-term care facilities in Queensland, Australia. Information extracted included the types and usage of regular and Pro Re Nata central nervous system medications. Results: Of those taking medication (n=317), 68% were prescribed at least one potentially inappropriate medication, and there was a significant positive correlation between the number of medications prescribed and the number of potentially inappropriate medications. Two-hundred potential interactions with variable severity were identified from 130 residents on ≥ 1 medication – 38% were potentially severe interactions, 46% were moderate. Conclusion: This medication audit raises concerns that prescription of medications may still be the first resort to treat behavioural and psychological symptoms of dementia. There is a need for effective and sustainable person-centred interventions that address barriers for appropriate prescribing practice, and involve the collaboration of all healthcare professionals to optimise prescribing and improve the quality of medicines in older people with dementia.

Journal Title

Current Drug Safety

Conference Title
Book Title
Edition
Volume

12

Issue

2

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)

NHMRC

Grant identifier(s)

APP1065320

Rights Statement
Rights Statement

© 2017 Bentham Science Publishers. This is an open-access article distributed under the terms of Bentham Science Open Access Plus license (http://benthamscience.com/open-access-plus-main.php) which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The published manuscript is available at EurekaSelect via 10.2174/1574886312666170209113203.

Item Access Status
Note
Access the data
Related item(s)
Subject

Clinical sciences

Traditional, complementary and integrative medicine

Pharmacology and pharmaceutical sciences

Pharmacology and pharmaceutical sciences not elsewhere classified

Persistent link to this record
Citation
Collections