An efficient microfluidic sorter: Implementation of double meandering micro striplines for magnetic particles switching

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Kong, Tian Fook
Shin E, Huan
Sugiarto, Hendrik Santoso
Liew, Hwi Fen
Wang, Xinghua
Lew, Wen Siang
Nguyen, Nam-Trung
Chen, Yong
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2011
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Abstract

The ability to trap, manipulate, and separate magnetic beads has become one of the key requirements in realizing an integrated magnetic lab-on-chip biosensing system. In this article, we present the design and fabrication of an integrated magneto-fluidic device for sorting magnetic particles with a sorting efficiency of up to 95%. The actuation and manipulation of magnetic beads are realized using microfabricated square meandering current-carrying micro striplines. The current is alternated between two neighboring micro striplines to switch the magnetic beads to either one of the two outlets. We performed a series of parametric study to investigate the effect of applied current, flow rate, and switching frequency on the sorting efficiency. Experimental results reveal that the sorting efficiency is proportional to the square of current applied to the stripline, and decreases with increasing buffer flow rate and switching frequency. Such phenomena agree well with our theoretical analysis and simulation result. The fastest switching rate, which is limited by the microchannel geometry and bead velocity, is 2 Hz.

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Microfluidics and Nanofluidics

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10

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5

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© 2011 Springer Berlin Heidelberg. This is an electronic version of an article published in Microfluidics and Nanofluidics, Volume 10, Issue 5, pp 1069-1078, 2011. Microfluidics and Nanofluidics is available online at: http://link.springer.com/ with the open URL of your article.

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Mechanical engineering

Engineering practice and education not elsewhere classified

Nanotechnology

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