18F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology

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Kalimuddin, S
Xie, W
Watanabe, S
Tham, JY
Sam, H
Chan, KWK
Yap, TS
Totman, JJ
Chacko, AM
Vasudevan, SG
Low, JG
Griffith University Author(s)
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2021
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Abstract

In mouse models of dengue virus (DENV) infection, 18F-FDG PET is able to sensitively detect tissue-specific sites of inflammation and disease activity, as well as track therapeutic response to anti- DENV agents. However, the use of 18F-FDG PET to study the pathogenesis of inflammation and disease activity in DENV infection in humans, has not been clinically validated. Here we report the 18F-FDG PET imaging results of two patients during the febrile phase of acute DENV infection, paired with serial serum viral load, NS1 and proinflammatory cytokine measurements. Our findings demonstrate that 18F-FDG PET is able to sensitively detect and quantify organ-specific inflammation in the lymph nodes and spleen, in classic acute dengue fever. This raises the potential for 18F-FDG PET to be used as a research tool that may provide further insights into disease pathogenesis.

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Antiviral Research

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185

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© The Author(s) 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.

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Microbiology

Medical microbiology

Pharmacology and pharmaceutical sciences

Dengue

FDG-PET

Inflammation

Pathogenesis

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Kalimuddin, S; Xie, W; Watanabe, S; Tham, JY; Sam, H; Chan, KWK; Yap, TS; Totman, JJ; Chacko, AM; Vasudevan, SG; Low, JG, 18F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology, Antiviral Research, 2021, 185

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