Botryllamides K and L, new tyrosine derivatives from the Australian ascidian Aplidium altarium
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Cullinane, Carleen
Carroll, Anthony R
Quinn, Ronald J
Davis, Rohan A
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Abstract
Chemical investigation of the Australian ascidian Aplidium altarium led to the isolation of two new tyrosine derivatives, botryllamides K (1) and L (2), together with six known metabolites, botryllamides A-C (3-5), botryllamide G (6) and perspicamides A (7) and B (8). The structures of these compounds were elucidated by spectroscopic analysis. This is the first reported chemistry from this species. Compounds 1-8 were evaluated for their cytotoxicity towards the tumour cell lines, MCF-7 (breast), H460 (lung) and SF268 (central nervous system).
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Tetrahedron Letters
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51
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26
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© 2010 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
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Medicinal and biomolecular chemistry
Organic chemistry
Natural products and bioactive compounds
Biochemistry and cell biology