MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy

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Elad, Sharon
Cheng, Karis Kin Fong
Lalla, Rajesh V
Yarom, Noam
Hong, Catherine
Logan, Richard M
Bowen, Joanne
Gibson, Rachel
Saunders, Deborah P
Zadik, Yehuda
Ariyawardana, Anura
Correa, Maria Elvira
Ranna, Vinisha
Bossi, Paolo
Nair, Raj
et al.
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Background: Mucositis is a significant toxicity of cancer therapy with numerous systemic sequelae. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for the management of mucositis. Methods: The literature was reviewed systematically to identify interventions for mucositis. Studies were rated according to the presence of major and minor flaws according to previously published criteria. The body of evidence for each intervention and in each treatment setting was assigned a level of evidence based on previously published criteria. Guidelines were developed based on the level of evidence, with 3 possible guideline determinations: recommendation, suggestion, or no guideline possible. Results: The guideline covers evidence from 1197 publications related to oral or gastrointestinal mucositis. Thirteen new guidelines were developed for or against the use of various interventions in specific treatment settings, and 11 previous guidelines were confirmed after aa review of new evidence. Thirteen previously established guidelines were carried over because there was no new evidence for these interventions. Conclusions: The updated MASCC/ISOO Clinical Practice Guidelines for mucositis provide professional health caregivers with a clinical setting-specific, evidence-based tool to help with the management of mucositis in patients who have cancer.

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© 2020 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Elad, S; Cheng, KKF; Lalla, RV; Yarom, N; Hong, C; Logan, RM; Bowen, J; Gibson, R; Saunders, DP; Zadik, Y; Ariyawardana, A; Correa, ME; Ranna, V; Bossi, P; Nair, R, et al, MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy, Cancer, 2020, 126 (19), pp. 4423-4431