Selective cytotoxic Ru(II) arene Cp* complex salts [R-PhRuCp*]+X- for X = BF4-, PF6-, and BPh4-
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Healy, Peter C
Parsons, Peter G
Williams, Michael L
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Arlene Bristol, Richard Eisenberg (Editor-in-Chief)
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Abstract
A novel series of ionic Ru(II) arene Cp* sandwich complexes has been synthesized and characterized. Screening results for cytotoxicity against a range of human tumor cell lines and normal human cells indicate that the complexes show promising anticancer activity, which varies with changes in the arene ligand and the anionic counterion. Thus, reaction of RuCl3 with pentamethylcyclopentadiene in presence of propiophenone followed by reaction with NaPh4 in water gave 76% [Cp*Ru(.eta.6-C6H5COPr)]BPh4 (crystal structure); the anticancer activity of which was detd.
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Inorganic Chemistry
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47
Issue
19
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© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. The contents of this journal can be freely accessed online via the ACS web page 12 months after publication. Use hypertext link above to access the ACS website.
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Inorganic chemistry
Physical chemistry
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