Cardiac perturbations after high-intensity exercise are attenuated in middle-aged compared to young endurance athletes: diminished stress or depleted stimuli?

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Balmain, Bryce N
Sabapathy, Surendran
Yamada, Akira
Shiino, Kenji
Chan, Jonathan
Haseler, Luke J
Kavanagh, Justin J
Morris, Norman R
Stewart, Glenn M
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2020
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Abstract

Strenuous exercise elicits transient functional and biochemical cardiac imbalances. Yet, the extent to which these responses are altered due to aging is unclear. Accordingly, echocardiograph-derived left (LV) and right (RV) ventricular global longitudinal strain (GLS), and high-sensitivity cardiac troponin I (hs-cTnI) were assessed before (pre) and after (post) a 60min high-intensity cycling race intervention (CRIT60) in 11 Young (18-30 y) and 11 Middle-aged (40-65 y) highly-trained male cyclists, matched for cardiorespiratory fitness. LV and RV GLS, were measured at rest and during a semi-recumbent exercise challenge performed at the same intensity (Young: 93±10; Middle-aged: 85±11 W, p=0.60) pre- and post-CRIT60. Augmentation (change from rest-to-exercise challenge) of LV GLS (pre: -2.97±0.65; post: -0.82±0.48%, p=0.02) and RV GLS (pre: -2.08±1.28; post: 3.08±2.02%, p=0.01) were attenuated and completely abolished, respectively, in Young following the CRIT60, while augmentation of LV GLS (pre: -3.21±0.41; post: -3.99±0.55%, p=0.22) and RV GLS (pre: -3.47±1.44; post: -1.26±1.00%, p=0.27) were preserved in Middle-aged following the CRIT60. While serum hs-cTnI increased following the CRIT60 in Young (pre: 7.3±1.6; post: 17.7±1.6ng/L, p<0.01) and Middle-aged (pre: 4.5±0.6; post: 10.7±2.0ng/L, p<0.01), hs-cTnI increased to a greater extent in Young compared to Middle-aged following CRIT60 (p<0.01). These findings suggest that functional and biochemical cardiac perturbations induced by high-intensity exercise are attenuated in Middle-aged relative to Young individuals. Further study is warranted to determine whether acute exercise-induced cardiac perturbations alter the adaptive myocardial remodeling response.

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American Journal of Physiology-Heart and Circulatory Physiology

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© 2020 American Physiological Society . This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.

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Zoology

Medical physiology

Cardiovascular medicine and haematology

Age

Athletes Heart

Cardiac Troponin

Echocardiography

Remodelling

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Citation

Balmain, BN; Sabapathy, S; Yamada, A; Shiino, K; Chan, J; Haseler, LJ; Kavanagh, JJ; Morris, NR; Stewart, GM, Cardiac perturbations after high-intensity exercise are attenuated in middle-aged compared to young endurance athletes: diminished stress or depleted stimuli?, American Journal of Physiology-Heart and Circulatory Physiology, 2020

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