Evaluation of natural resveratrol multimers as marine antifoulants

Loading...
Thumbnail Image
Files

Davis8461307.pdf (704.62 KB)

File version
Accepted Manuscript (AM)
Author(s)
Davis, Rohan A
Cervin, Gunnar
Beattie, Karren D
Rali, Topul
Fauchon, Marilyne
Hellio, Claire
Akerlund, Lovisa Bodin
Pavia, Henrik
Svenson, Johan
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2023
Size
File type(s)
Location
License
http://creativecommons.org/licenses/by-nc/4.0/
Abstract

In the current study we investigate the antifouling potential of three polyphenolic resveratrol multimers (–)-hopeaphenol, vaticanol B and vatalbinoside A, isolated from two species of Anisoptera found in the Papua New Guinean rainforest. The compounds were evaluated against the growth and settlement of eight marine microfoulers and against the settlement and metamorphosis of Amphibalanus improvisus barnacle cyprids. The two isomeric compounds (–)-hopeaphenol and vaticanol B displayed a high inhibitory potential against the cyprid larvae metamorphosis at 2.8 and 1.1 μM. (–)-Hopeaphenol was also shown to be a strong inhibitor of both microalgal and bacterial adhesion at submicromolar concentrations with low toxicity. Resveratrol displayed a lower antifouling activity compared to the multimers and had higher off target toxicity against MCR-5 fibroblasts. This study illustrates the potential of natural products as a valuable source for the discovery of novel antifouling leads with low toxicity.

Journal Title
Biofouling
Conference Title
Book Title
Edition
Volume
Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
This is an Accepted Manuscript version of the following article, accepted for publication in Biofouling. Rohan A. Davis, Gunnar Cervin, Karren D. Beattie, Topul Rali, Marilyne Fauchon, Claire Hellio, Lovisa Bodin Åkerlund, Henrik Pavia & Johan Svenson (2023) Evaluation of natural resveratrol multimers as marine antifoulants, Biofouling, 39:8, 775-784, DOI: 10.1080/08927014.2023.2263374. It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject
Biological sciences
Environmental sciences
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Marine & Freshwater Biology
Antifouling
Persistent link to this record
Citation
Davis, RA; Cervin, G; Beattie, KD; Rali, T; Fauchon, M; Hellio, C; Akerlund, LB; Pavia, H; Svenson, J, Evaluation of natural resveratrol multimers as marine antifoulants, Biofouling, 2023, 39 (8), pp. 775-784
Collections