Novel cytotoxic constituents of Orthosiphon diffusus

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Holla, Harish
Srinivas, Yallamalla
Majhi, Anjoy
Srinivasulu, Gannoju
Sridhar, Balasubramanian
Krishna, Arepalli Sai
Rao, Janapala Venkateswara
Das, Biswanath
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2011
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Abstract

Chemical investigation on Orthosiphon diffusus resulted in the isolation of four relatively rare, novel polychiral furanopyrans, orthodiffenes A-D (1-4) which were characterized from detailed studies of their 1D and 2D NMR spectra. The X-ray crystallographic analysis of orthodiffene A (1) was accomplished. The in vitro cytotoxic activity of orthodiffenes A-C (1-3) was tested against Jurkat and HL-60 cells using camptothecin as a positive control. Orthodiffenes A (1) and B (2) showed comparable activity to camptothecin against HL-60 and Jurkat cells, respectively.

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Tetrahedron Letters

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52

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1

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Natural Products Chemistry

Medicinal and Biomolecular Chemistry

Organic Chemistry

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